KEITEL H
Keitel h
INTRODUCTION
KEITEL H 40MG is a combination of Hydrochlorothiazide and Telmisartan which belongs to the group of medicines called Thiazide diuretics and Angiotensin-receptor blockers respectively. KEITEL H 40MGis used to control high blood pressure among adults whose blood pressure could not be adequately controlled by single agents. High blood pressure (also known as Hypertension) is a medical condition in which the force of the blood exerted against the walls of the artery remains very high, and as a result it may lead to severe damage to the blood vessels of several organs, thus causing heart attack, heart or kidney failure, stroke, or even blindness.
Telmisartan is an Angiotensin-receptor blocker which effectively reduces blood pressure by blocking the actions of Angiotensin – II (a substance that causes narrowing of blood vessels and increase in blood pressure) and hydrochlorothiazide is a diuretic which acts by increasing urine output, thus leading to a decrease in blood pressure. During the course of therapy, your doctor might regularly monitor your blood pressure, kidney function and electrolytes balance at regular intervals to avoid any untoward side effects.
Take this medicine with or without food. Before taking KEITEL H 40MG, inform your doctor. if you have any problems related to kidney, liver, lungs, or heart and if you have other conditions such as diabetes, gout, hyperaldosteronism, and skin cancer. Long-term use of this medicine may increase the risk of some types of skin and lip cancer, and therefore always protect your skin from sun rays and UV exposure. KEITEL H 40MGis not recommended for use in children and adolescents less than 18 years of age. KEITEL H 40MGshould not be used in pregnant women (especially after 3 months of gestation), as it may cause potential harm to the unborn baby. The most common side effect of taking KEITEL H 40MGis dizziness. Consult your doctor if the symptom gets worsen over the time.
USES OF KEITEL H 40MG
- Treats high blood pressure
HOW KEITEL H 40MG WORKS
KEITEL H 40MGhelps to control high blood pressure where Telmisartan acts by blocking the actions of Angiotensin – II, which leads to relaxation of blood vessels, and hydrochlorothiazide acts by increasing urine output, thus leading to a decrease in blood pressure.
DIRECTIONS FOR USE
Take KEITEL H 40MG as advised by your doctor. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending upon your age, body weight and disease condition.
SIDE EFFECTS OF KEITEL H 40MG
COMMON
- Dizziness
UNCOMMON
- Signs of decreased potassium levels (constipation, muscle damage and weakness, palpitations)
- Anxiety, fainting
- Sensation of tingling and prickling sensation in arms, legs, or feet
- Feeling of spinning (vertigo)
- Fast heartbeat, heart rhythm disorders
- Low blood pressure
- Orthostatic hypotension (low blood pressure when standing up)
- Shortness of breath
- Diarrhea
- Dry mouth
- Flatulence
- Back pain, muscle spasm, muscle pain
- Erectile dysfunction (inability to get or keep an erection)
- Chest pain
RARE
- Inflammation of lung
- Worsening of systemic lupus erythematosus (an auto-immune disease characterized by joint pain, skin rashes and fever)
- Sore throat, inflamed sinuses
- Depression
- Difficulty in falling asleep
- Blurred vision
- Difficulty in breathing
- Stomach pain, constipation, bloating, vomiting
- Redness of skin
- Allergic reactions (such as itching or rash, increased sweating, hives, joint pain and pain in extremities, muscle cramps and flu-like symptoms)
Stop taking KEITEL H 40MG and contact your doctor immediately if you experience any of the following side effects:
- Sepsis (a severe infection with an inflammatory response in the entire body, rapid swelling of skin and mucosa and blistering and peeling of top layer of skin)
HOW TO MANAGE SIDE EFFECTS
Dizziness:
Try to rest and relax. Get enough sleep. Avoid driving or operating any machines while you are feeling dizzy. Consult your doctor if you are worried about this.
Vomiting:
Take this medicine with or just after meal or snack. Stick to simple meals and avoid rich or spicy food. Consult your doctor if the symptom does not improve.
Bloating:
Eat smaller and frequent meals. Eat and drink slowly, and exercise regularly. If the symptoms get worse, contact your doctor.
Constipation:
Eat lots of fibre rich foods like fruits, vegetables and cereals. Drink plenty of water. Exercise more regularly. Consult your doctor if the symptom does not improve.
Stomach pain:
Try to rest and relax. You can eat and drink slowly or have smaller and frequent meals. Keep a heat pad on your stomach may also help. Consult your doctor if the pain is more severe.
Skin redness or itching:
Avoid hot showers because hot water can irritate your skin more. Do not scratch the affected area. Avoid sun exposure or UV rays as it may sensitize your skin. Use sunscreen and protective clothing when outdoors. Regularly moisturize your skin. If the symptoms did not vanish, consult your doctor.
WARNING & PRECAUTIONS
PREGNANCY
KEITEL H 40MGis not recommended for use in pregnant women and should not be used if you are more than 3 months pregnant, as it may cause serious harm to your baby. Consult your doctor for advice before taking KEITEL H 40MG.
BREASTFEEDING
KEITEL H 40MGis not recommended for use in breast-feeding mothers. Consult your doctor for advice before taking KEITEL H 40MG.
DRIVING AND USING MACHINES
Do not drive or operate any machines if you experience tiredness or dizziness.
ALCOHOL
Avoid consumption of alcohol while taking this medicine, because it may increase the risk of low blood pressure (causing dizziness or fainting). Consult your doctor for advice before taking KEITEL H 40MG.
KIDNEY
KEITEL H 40MGis not recommended for use in patients having severe kidney disease. It should be used with caution in patients with kidney artery stenosis (narrowing of the blood vessels to one or both kidneys), kidney disease and with surgical history of kidney transplant. Consult your doctor for advice before taking KEITEL H 40MG.
LIVER
KEITEL H 40MGis not recommended for use in patients having liver problems such as cholestasis or biliary obstruction or any other severe liver disease and it should be used with caution in patients with liver disease. Consult your doctor for advice before taking KEITEL H 40MG.
ALLERGY
Do not take KEITEL H 40MGif you are allergic to Telmisartan or Hydrochlorothiazide or sulphonamides such as sulfamethoxazole.
HEART DISEASE
KEITEL H 40MGshould be used with caution if you have any heart problems. Consult your doctor for advice before taking KEITEL H 40MG.
OTHERS
KEITEL H 40MG s not recommended for you, if you have:
- Hypokalemia (decreased blood potassium levels) or hypercalcemia (increased blood calcium levels) (which is not improved with treatment)
Before taking KEITEL H 40MG, inform your doctor if you have:
- Low blood pressure (due to dehydration, salt deficiency, low-sodium diet, diarrhea, vomiting, or hemodialysis)
- Diabetes
- Gout (pain in joints)
- Increased aldosterone levels (characterized by salt and water retention with imbalance of various blood minerals)
- Systemic lupus erythematosus (an auto-immune skin disease)
- Skin cancer
- Any upcoming surgery
Use in pediatrics:
KEITEL H 40MGis not recommended for use in children and adolescents less than 18 years of age. Consult with your doctor for advice before taking KEITEL H 40MG.
Use in geriatrics:
KEITEL H 40MGshould be used with caution in elderly patients above 65 years of age, usually initiating the treatment with the lowest effective and depending upon kidney, liver or heart function. Consult with your doctor for advice before taking KEITEL H 40MG.
INTERACTIONS
A. Drug-Drug Interaction:
Before taking KEITEL H 40MG inform to your doctor, if you are taking any of these medicines:
- Medicines that cause low blood potassium levels (such as other diuretics (Ex. furosemide), laxatives (Ex. castor oil), corticosteroids (Ex. prednisone), cortisol, amphotericin, carbenoxolone, penicillin G sodium and salicylic acid)
- Medicines that increase blood potassium levels (such as potassium-sparing diuretics (Ex. spironolactone), potassium supplements, ACE inhibitors (Ex. captopril, enalapril), cyclosporin and heparin)
- Medicines used to treat abnormal heart rate (Ex. digoxin, quinidine, disopyramide, amiodarone, sotalol)
- Medicines used to treat mental disorders (Ex. chlorpromazine, thioridazine, levomepromazine)
- Antibiotics (used to treat infections) Ex. sparfloxacine, pentamidine
- Medicines used to treat allergic reactions (Ex. terfenadine)
- Medicines used to treat diabetes (metformin, insulin)
- Medicines used to reduce blood cholesterol levels (Ex. cholestyramine and colestipol)
- Medicines used to increase blood pressure (Ex. noradrenaline)
- Muscle relaxants (Ex. tubocurarine, baclofen)
- Calcium supplements and/or vitamin D supplements
- Anti-cholinergic medicines (used to treat various disorders such as urinary bladder spasm, asthma, motion sickness) (Ex. atropine and biperiden)
- Amantadine (used to treat Parkinson’s disease)
- Other medicines used to treat high blood pressure (such as aliskiren, ACE inhibitors (Ex. captopril, enalapril), calcium channel blockers (Ex. diltiazem, verapamil), Angiotensin receptor blockers (Ex. losartan, valsartan)
- Corticosteroids (used to treat pain and inflammation) Ex. prednisone
- Non-steroidal anti-inflammatory drugs (NSAIDs) (used to treat pain) Ex. aspirin, diclofenac, ibuprofen
- Medicines to treat cancer, gout, or arthritis (Ex. methotrexate)
- Barbiturates such as pentobarbital, phenobarbital (used to treat anxiety and seizures)
- Amifostine (used to protect kidneys during chemotherapy)
- Lithium and antidepressants such as paroxetine, sertraline (used to treat depression)
Overdosage:
If you or anyone else accidentally take too much of KEITEL H 40MG, consult your doctor immediately. Overdosage may cause undesirable effects such as low blood pressure, rapid heartbeat, vomiting, slow heartbeat, dizziness, low blood levels of potassium (resulting in nausea, sleepiness and muscle cramps or irregular heartbeat), reduced kidney function including kidney failure.
SYNOPSIS
| Drug | : | Hydrochlorothiazide, Telmisartan |
| Pharmacological Category | : | Thiazide diuretics, Angiotensin – receptor blocker |
| Therapeutic Indication | : | High blood pressure |
| Dosage Forms | : | Tablet |
MORE INFORMATION
- Keep out of reach of children
- Store at room temperature
FAQs ABOUT KEITEL H 40MG
Is KEITEL H 40MG safe to use during pregnancy?
KEITEL H 40MG is not recommended for use in pregnant women and should not be used if you are more than 3 months pregnant, as it may cause serious harm to your baby. Inform your doctor if you are planning to get pregnant or if you think you are pregnant. Always, consult your doctor before taking KEITEL H 40MG.
Can I consume alcohol while taking KEITEL H 40MG?
No. Avoid consumption of alcohol while taking TELVAS H 40MG, because it may increase the risk of low blood pressure (causing dizziness or fainting). Consult your doctor for advice before taking KEITEL H 40MG.
What to do If I forget to take KEITEL H 40MG?
You should take KEITEL H 40MG immediately when you remember. If it is time for your next dose skip the dose and follow your regular dose schedule. Do not double the dose to match up your missed dose.
Does KEITEL H 40MG increases urination?
Yes, KEITEL H 40MG contains hydrochlorothiazide a diuretic agent which works by removing excess fluid from the body through kidneys which leads to increased passage of urination. Excess water loss in body may result in dehydration. During treatment with KEITEL H 40MG if you are always feeling tired, thirsty, or you have muscle cramps constantly, immediately consult your doctor for advice.
Can KEITEL H 40MG cause photosensitivity reactions?
Yes, KEITEL H 40MG may cause patients to become more sensitive to sunlight or ultraviolet radiation. Avoid going out or minimize the exposure of natural sunlight or artificial UV rays. In case of while going out protect your skin by applying sunscreen protection cream with the approval of your doctor which helps to prevent sunburn allergy reactions. Inform your doctor if you have previous history of skin problems before taking KEITEL H 40MG.
Can KEITEL H 40MG be used in elderly individuals?
KEITEL H 40MGshould be used with caution in elderly patients above 65 years of age, usually initiating the treatment with the lowest effective and depending upon liver, kidney, or heart function. During treatment with KEITEL H 40MG if you feel any unusual symptoms consult your doctor immediately.
What is KEITEL H 40MG used for?
KEITEL H 40MG is used to control high blood pressure among adults whose blood pressure could not be adequately controlled by single agents. KEITEL H 40MG is not recommended for use in children or adolescents less than 18 years of age.
REFERENCES
1. KD. Tripathi. Antihypertensive Drugs. Essentials of medical pharmacology. Seventh edition. 2013. Page – 559.
2. KD. Tripathi. Drugs Affecting Renin-Angiotensin System and Plasma Kinins. Essentials of medical pharmacology. Seventh edition. 2013. Page – 505-508.
3. Randa Hilal-Dandan. Renin and Angiotensin. Goodman & Gilman’s: The Pharmacological basics of Therapeutics. 12th Edition. New York McGraw Hill Medical 2011. Page – 738.
4. Boehringer Ingelheim. 3 x 3 Factorial Trial of Telmisartan and Hydrochlorothiazide in Patients with Essential Hypertension. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in November 2013] [Accessed on 17th August 2021] https://clinicaltrials.gov/ct2/show/NCT00153049
5. Boehringer Ingelheim. Telmisartan 80mg Plus Hydrochlorothiazide 25mg First Line in Moderate or Severe Hypertension. NIH U.S. National Library of Medicine ClinicalTrials.gov. [Revised in June 2014] [Accessed on 17th August 2021] https://clinicaltrials.gov/ct2/show/NCT00926289
6. Roland E Schmieder. Telmisartan/hydrochlorothiazide combination therapy in the treatment of essential hypertension. NIH National Library of Medicine, National center for biotechnology information. Pubmed.gov. November 2004. [Accessed on 17th August 2021] https://pubmed.ncbi.nlm.nih.gov/15500377/
7. Roberto Fogari, Annalisa Zoppi, Amedeo Mugellini, Paola Preti, Maurizio Destro, Andrea Rinaldi, and Giuseppe Derosa. Effectiveness of hydrochlorothiazide in combination with telmisartan and olmesartan in adults with moderate hypertension not controlled with monotherapy: a prospective, randomized, open-label, blinded end point (PROBE), parallel-arm study. NCBI; PMC US National Library of Medicine, National Institute of Health. February 2008. [Accessed on 17th August 2021] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3969955/
8. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in June 2020] [Accessed on 17th August 2021] https://www.medicines.org.uk/emc/files/pil.8605.pdf
9. Cipla Ltd. CRESAR-H Tablets (Telmisartan + Hydrochlorothiazide). Ciplamed. [Revised in September 2020] [Accessed on 17th August 2021] https://www.ciplamed.com/content/cresar-h-tablets
USEFUL DIAGNOSTIC TESTS
- Kidney function test